Polymorphism in ABC transporter genes of Dirofilaria immitis
نویسندگان
چکیده
منابع مشابه
Polymorphism in ABC transporter genes of Dirofilaria immitis
Dirofilaria immitis, a filarial nematode, causes dirofilariasis in dogs, cats and occasionally in humans. Prevention of the disease has been mainly by monthly use of the macrocyclic lactone (ML) endectocides during the mosquito transmission season. Recently, ML resistance has been confirmed in D. immitis and therefore, there is a need to find new classes of anthelmintics. One of the mechanisms ...
متن کاملABC-B transporter genes in Dirofilaria immitis
Dirofilaria immitis is a filarial nematode causing infection and heartworm disease in dogs and other canids, cats, and occasionally in humans. Prevention with macrocyclic lactones (ML) is recommended during the mosquito transmission season. Recently, ML resistance has been reported. ABC-B transporter genes are thought to be involved in the mechanism of ML resistance in other nematodes. This stu...
متن کاملGenetic polymorphism in Dirofilaria immitis.
Dirofilaria immitis is the causative agent of heartworm disease. Reports of macrocyclic lactone inefficacy prompted an investigation of genetic polymorphism in D. immitis. Currently, there is a lack of genetic information for this parasite. Information on baseline levels of genetic heterogeneity in the dog heartworm would have important implications for the possible development of macrocyclic l...
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Dirofilaria immitis, a filarial parasite, causes cardiopulmonary dirofilariasis in dogs, cats and wild canids. The macrocyclic lactone (ML) class of drugs has been used to prevent heartworm infection. There is confirmed ML resistance in D. immitis and thus there is an urgent need to find new anthelmintics that could prevent and/or control the disease. Targeting ion channels of D. immitis for dr...
متن کاملFeline Dirofilaria immitis infection
AffectedAnimals: Dogs and cats. Overall, cats are infected by heartworms much less commonly, even in areas in which heavily infected dogs are present. Male cats tend to be infected more commonly and have a larger worm burden than female cats, mostly because male cats spend more time roaming outside and have less resistance to infection than female cats. Cats that spend significant amounts of ti...
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ژورنال
عنوان ژورنال: International Journal for Parasitology: Drugs and Drug Resistance
سال: 2017
ISSN: 2211-3207
DOI: 10.1016/j.ijpddr.2017.04.004